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LC/MS Analysis of Drugs in BSA (1) (ODP2 HP)

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LC/MS analysis of drugs in BSA was performed using polymer-based column ODP2 HP. Each drug has peak areas between 83 -100 % (peak areas without BSA are set as 100 %), which means a good separation without receiving ion suppression from protein.


Sample : drugs 500ng/mL each in BSA (7.0mg/L), 5μL
Lidocaine
Chlorpheniramine
Propranolol
Diphenhydramine
Bupivacaine
Verapamil
Imipramine


Column       : Shodex ODP2 HP-2B (2.0mmI.D. x 50mm)
Eluent       : 10mM Ammonium acetate aq./CH3CN=70/30
Flow rate    : 0.2mL/min
Detector     : UV(280nm), ESI-MS (SIM Positive)
Column temp. : 40°C