Chiral ORpak CDBS-453 column
with β-Cyclodextrin derivatives
For the separation of Epinephrine and other chiral drugs
Product information
In the fields of medicine, agricultural chemicals and food, it is important to analyze optical isomers to confirm physiological activity or to measure optical purity of optical isomers. Shodex offers one type of separation column of chiral separation.
ORpak CDBS-453
The ORpak CDBS-453 column is packed with silica-based gel bonded with β-cyclodextrin derivatives as ligand.
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Separates optical isomers by using their conformational compatibility differences
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Versatile column for chiral separation
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Fulfills USP L45 requirements
Analytes: Epinephrine, Norepinephrine, Lamivudine, Voriconazole and other chiral drugs
Example:
Sample: 20 μL Epinephrine (racemic mixture) 50 μg/mL (in eluent)
Column: Shodex ORpak CDBS-453 (4.6 x 150 mm)
Eluent: (0.05 % (w/v) CH3COOH + 0.2 M NaCl) aq./CH3CN=95/5
Flow rate: 0.5 mL/min
Detector: UV (280 nm)
Column temp.: 10°C
Product overview
Product code | Product name | Separation | Functional group | Gel material | Particle size | Pore size | Size (ID x length) | Housing material |
|---|---|---|---|---|---|---|---|---|
F7146003 | ORpak CDBS-453 | Chiral | beta-Cyclodextrin derivate | Silica | 3 µm | - | 4.6 x 150 mm | steel |
Product details
Product name | Maximum pressure | Maximum flow rate | Temperature range | pH range | Salt concentration | Shipping solvent | USP |
|---|---|---|---|---|---|---|---|
ORpak CDBS-453 | 20 MPa (200 bar) | 1.2 mL/min | 5 to 60°C | 2 to 7.5 | ≤ 1.0 M | (0.05 % CH3COOH + 0.2 M NaCl aq.)/CH3CN/ = 95/5 | L45 |